Press Release Details

View all news

Can genetics affect the need for surgery in patients with thumb osteoarthritis?

01/24/2024

Rhizarthrosis, also known as trapeziometacarpal osteoarthritis, is a type of osteoarthritis that affects the thumb, and treatments range from splints to surgery. Investigators have uncovered various genetic differences between individuals with rhizarthrosis who undergo surgery for their condition versus those who opt for nonsurgical treatments.

The study, which is published in the Journal of Orthopaedic Research, included 1,083 surgical patients and 1,888 nonsurgical patients with rhizarthrosis, as well as 205,371 controls without osteoarthritis.

Researchers identified 7 genetic variants that may be associated with surgical rhizarthrosis and 3 variants suggestively associated with nonsurgical rhizarthrosis. They noted that uncovering genetic differences between these patient groups may reveal biological mechanisms that affect various aspects of rhizarthrosis.

“Our findings delve into the genetic architecture of osteoarthritis in the thumb base, hinting at a potential genetic influence on the need for surgery,” said corresponding author Cecilie Henkel, MD, PhD, of Copenhagen University Hospital Hvidovre, in Denmark. “While no solid conclusions about the effect of specific genetic variants on the need for surgical treatment should be made at this stage, our study marks a stride towards integrating genetic insights into the clinical management of osteoarthritis, with the long-term aim of refining diagnosis, treatment, and preventative strategies for this common and debilitating disease.”

URL: https://onlinelibrary.wiley.com/doi/10.1002/jor.25753


Additional Information
NOTE: 
The information contained in this release is protected by copyright. Please include journal attribution in all coverage. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, newsroom@wiley.com.

About the Journal
The Journal of Orthopaedic Research, a publication of the Orthopaedic Research Society, is the forum for the rapid publication of high quality reports of new information on the full spectrum of orthopaedic research, including life sciences, engineering, translational, and clinical studies.

About Wiley
Wiley is a knowledge company and a global leader in research, publishing, and knowledge solutions. Dedicated to the creation and application of knowledge, Wiley serves the world’s researchers, learners, innovators, and leaders, helping them achieve their goals and solve the world's most important challenges. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on FacebookTwitterLinkedIn and Instagram.

Multimedia Files:

View all news